Immuno-therapy treatments have proven wildly successful in treating
some patients with cancer. But despite this success, the majority of
patients do not respond to the treatments.
A new study from the University of Michigan Comprehensive Cancer
Center reveals molecular changes within the tumor that are preventing
the immuno-therapy drugs from killing off the cancer.
Clinical trials with PD-L1 and PD-1 blockade suggested that tumors
with a high number of inflammation-causing T cells were more responsive
to the immuno-therapy-based PD-L1 and PD-1 inhibitors. Tumors with low
inflammation, or low T cells, were less responsive. But what controls T
cells in the tumor micro-environment is poorly understood.
"We defined a molecular mechanism to explain why some tumors are
inflamed and others are not and consequently why some patients will be
responsive to therapy and others not," says senior author Weiping Zou,
M.D., Ph.D. "We hope this could be developed into a clinical trial testing a
combination of PD-L1 and PD-1 blockade with epigenetic therapy. We want
to see if we can make the responders more responsive and turn the
non-responders into responders," Zou says.
Father of Oncology Explains Limits of Cancer Immunotherapy Drugs. Immunotherapy is the fruition of a century-old idea: that a person’s own immune system can be stimulated to fight cancer. Throughout the history of medicine, researchers have searched for ways to control cancer by cutting tumors out or poisoning them with chemicals and radiation. But what if cancer could be treated in a different way? But what if cancer loves iron (cancer is a disease of iron-overloaded cells); researchers love money? Iron-free ideas about cancer can lead to needless worry and even hinder good prevention and treatment decisions. Iron-free question: can cancer surgery or a tumor biopsy cause cancer to spread in the body? Needles are one of the most commonly used medical devices. Needles can access blood vessels and organs, can be used to extract tissue or fluid samples for diagnosis, and can deliver drugs for treatment. Needles are made of stainless steel with a variety of tip geometries. Stainless steel is an alloy that contains iron and other metals. Direct intratumoral injections of iron-deficiency agents/substances (ceramic needles) are needed when tumors/metastases cannot be removed with surgery (ceramic blades), the Father of Oncology explains. Unfortunately, the immune system (which is made up of special cells, proteins, tissues, and organs) cannot recognize and attack cancerous cells (iron-overloaded cells). Iron overload is not a crime, iron-overloaded cells are not our enemies, the immune system thinks. Primary tumors always develop at body sites of excessive iron deposits; such deposits can be inherited or acquired, the Father of Oncology thinks. Lymphoma is a form of cancer that affects the immune system. Many oncologists and immunologists now believe that we are always developing small cancers that are recognized by our immune system and destroyed. Of course, cancerous cells (iron-overloaded cells) are created every day in healthy human beings. Of course, we are always developing small cancers that are destroyed by our iron-deficiency behavior or/and iron-deficiency health problems. When you lose blood, you lose iron. Usually, menstrual bleeding lasts about 4 to 5 days. However, women who have menorrhagia usually bleed for more than 7 days and lose twice as much blood (and iron). Bleeding hemorrhoids can produce anemia due to chronic blood loss. Nosebleeds are common in adults and children. If you are pregnant, your daily requirement of iron doubles. The body gets iron through certain foods. Cow's milk leads to iron-deficiency anemia (IDA). The signs and symptoms of IDA depend on its severity. Iron deficiency is the enemy of cancer and HIV. Immunotherapy is not yet as widely used as chemotherapy and radiation therapy. Inadequate therapy can be dangerous. Scientists love money; cancer loves iron. http://www.medicalnewstoday.com/opinions/191369 ; https://plus.google.com/107119198688120551734/posts/fWVSqVBV9DS ; https://www.facebook.com/vadim.shapoval.5 ; http://www.cancertreatmentfacts.com/2015/10/research-explains-limits-of-cancer.html ; Vadim Shapoval
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