Compared with just one copy in humans, elephants' cells contain 20
copies of a major cancer-suppressing gene, two teams of scientists
report. The gene helps damaged cells repair themselves or self-destruct
when exposed to cancer-causing substances.
The findings aren't proof that those extra p53 genes make elephants
cancer-resistant, but if future research confirms it, scientists could
try to develop drugs for humans that would mimic the effect.
Peto's paradox refers to the fact that large animals including
elephants and whales, have comparatively low cancer rates even though
they have many more cells than smaller species. Cancer involves
uncontrolled cell growth.Schiffman's team also analyzed necropsy data and found that elephants
sometimes live as long as humans, yet only about 1 in 20 die of cancer,
versus about 1 in 4 humans.
The second group of researchers, working with frozen zoo specimens,
looked at more than 60 other species and found only elephants and wooly
mammoths, their extinct relatives, had extra copies of the
cancer-suppressing gene.This team inserted elephants' p53 genes into mouse cells and found
that those cells behaved just like elephants and self-destructed when
exposed to DNA-damaging drugs.
Schiffman's team is seeking funding for research into possible treatments based on the elephant research.
This site is for information on the various Chemo treatments and Stem Cell Therapies since 1992. This journey became bitter sweet in 2014, with the passing of my beautiful and dear wife. Sherry, had fought Non - Hodgkins Lymphoma(NHL) since 1990, in and out of remissions time and time again. From T-Cell therapies(1990's) to Dual Cord Blood Transplant(2014), she was in Clinical Trials over the years. This site is for informational purpose only and is not to promote the use of certain therapies.
Subscribe to:
Post Comments (Atom)
No comments:
Post a Comment