The idea behind a new invention by scientists at Wake Forest Baptist
Medical Center's Institute for Regenerative Medicine. In the journal Biotechnology and Bioengineering,
the team reports on its "metastasis-on-a-chip" system believed to be
one of the first laboratory models of cancer spreading from one 3D
tissue to another.
The research team is working to further develop the system in hopes
that it can one day be used to quickly reveal the best way to treat an
individual patient's cancer.
"We believe the metastasis-on-a-chip system has potential for making
meaningful advances in cancer investigation and drug discovery," said
Aleks Skardal, Ph.D., lead author and an assistant professor of
regenerative medicine.
This is a relatively new focus of cancer research. For example, the
scientists learned that a "stiffer" tumor was more apt to metastasize,
suggesting the possibility of using drugs to alter the mechanical
properties of a tumor to reduce its likelihood of spreading.
The system has the potential to address some of the shortcomings of
current research methods. For example, the results from traditional 2D
studies in laboratory dishes as well as studies in animals often are not
applicable to human patients. Often, seemingly promising drug
candidates may fail when they reach studies in humans.
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