According to new research, DNA analysis of normal breast tissue can
be used to calculate a woman’s risk of developing breast cancer later in
life. The research team at the University College London took a look at
668 breast tissue samples from 50 cancer-free women and 42 women with
cancer. They analyzed both normal and cancerous tissue.
In more than 30 percent of cases, the research team found that the
alterations in DNA expression matched those of cancer samples. According
to researchers, this could indicate the reprogramming of cells from
normal to cancerous in patients.
According to the study papers, researchers said, “Importantly a large
component of the detected variable epigenetic signature was enriched in
the corresponding breast cancer tissue, supporting the view of the
researchers that this variable epigenetic signature marks susceptible
precursor cells crucially involved in breast cancer development.
Furthermore, those cases of breast cancer which were exhibiting
epigenetic changes were associated with significantly poorer prognosis
and a decreased level of survivorship from the disease.”
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