Acute lymphoblastic leukemia (ALL) is the most common type of cancer in
children. It can occur in various forms, differing not only by specific
changes in the genetic material of the leukemia cells but also by their
response to therapies. Now, an international team of scientists from
Berlin, Düsseldorf, Hannover, Heidelberg, Kiel, and Zurich have
succeeded in decoding the molecular characteristics of an as yet
incurable subtype of leukemia, paving the way for new therapeutic
approaches.
The consortium team decoded the genome of the leukemic cells using
sophisticated bioinformatics methods. The team found genetic aberrations
in addition to the known translocation. "We are glad that we could
contribute to this important project with genomic data analysis of
leukemia cells to unravel some of the molecular changes in this
disease", says Bodo Lange (CEO, Alacris Theranostics)."This technique provides a quantitative read out of the actual genetic
program occurring in the cancer cells, which allowed us to uncover
relevant molecular mechanisms cooperating to promote tumorigenesis, and
to identify possible druggable targets. These findings could only be
achieved through analysis of the messenger RNAs", says Marie-Laure
Yaspo.
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