In September 2015, then 44 year-old CEO of BioViva USA Inc. Elizabeth
Parrish received two of her own company's experimental gene therapies:
one to protect against loss of muscle mass with age, another to battle
stem cell depletion responsible for diverse age-related diseases and
infirmities.
It is already the world's first successful example of telomere
lengthening via gene therapy in a human individual. Gene therapy has
been used to lengthen telomeres before in cultured cells and in mice,
but never in a human patient.
Telomeres are short segments of DNA which cap the ends of every
chromosome, acting as 'buffers' against wear and tear. They shorten
with every cell division, eventually getting too short to protect the
chromosome, causing the cell to malfunction and the body to age.
In September 2015, telomere data taken from Parrish's white blood
cells by SpectraCell's specialised clinical testing laboratory in
Houston, Texas, immediately before therapies were administered, revealed
that Parrish's telomeres were unusually short for her age, leaving her
vulnerable to age-associated diseases earlier in life.
In March 2016, the same tests taken again by SpectraCell revealed
that her telomeres had lengthened by approximately 20 years, from 6.71kb
to 7.33kb, implying that Parrish's white blood cells (leukocytes) have
become biologically younger. These findings were independently verified
by the Brussels-based non-profit HEALES (HEalthy Life Extension
Company), and the Biogerontology Research Foundation, a UK-based charity
committed to combating age-related diseases.
BioViva will be testing new gene therapies and combination gene
therapies to restore age related damage. It remains to be seen whether
the success in leukocytes can expanded to other tissues and organs, and
repeated in future patients.
This site is for information on the various Chemo treatments and Stem Cell Therapies since 1992. This journey became bitter sweet in 2014, with the passing of my beautiful and dear wife. Sherry, had fought Non - Hodgkins Lymphoma(NHL) since 1990, in and out of remissions time and time again. From T-Cell therapies(1990's) to Dual Cord Blood Transplant(2014), she was in Clinical Trials over the years. This site is for informational purpose only and is not to promote the use of certain therapies.
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