Colon tumors that don't produce a protein called CDX2 are more likely to return following surgical removal in patients with stage 2 colon cancer, according to the study results.
Current standard practice holds that people with stage 2 colon cancer are not given chemotherapy following surgery to remove their tumors, because the risks of chemo outweigh the benefits, said study lead author Dr. Michael Clarke. He is a professor of cancer biology with the Stanford University School of Medicine in Palo Alto, Calif.
But at least 5 percent to 10 percent of stage 2 patients are CDX2-negative, and therefore could benefit if doctors added chemotherapy to their treatment, Clarke said.
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