Finding out what causes that genetic
mutation has been the holy grail of medical science for decades.
Researchers at the Texas A&M Health Science Center Institute of
Biosciences and Technology believe they may have found one of the
reasons why these genes mutate and it all has to do with how stem cells
talk to each other.The landmark studies by Texas A&M researchers Fen Wang, Ph.D., and Wallace McKeehan, Ph.D.,
studied a family of proteins that communicate between
cells called fibroblast growth factor (FGF). This new research shows
that errors in the way FGF is transmitted and received by cells can
activate previously dormant stem cells in an organ, which can cause cancer.
"FGF is truly the Cinderella of cancer research. For decades it has
been overlooked by big pharmaceutical companies because its role in
cells is so complex. Now that we are starting to understand it, everyone
is rushing to pay attention to the new star," said Wang, director of
the Texas A&M Center for Cancer and Stem Cell Biology. Nearly every cell in the body expresses the FGF protein, but there are
22 different types, so researchers have struggled to understand their
role in cell communication. Until recently it has been a mystery as to
how one of the 22 different types of FGF were sent out by cell
expressers and taken in by cell receivers.
Recent research has shown that FGF appears to play a major role in
breast and prostate cancer, which is why the duo decided to focus on the
protein's role. Wang and McKeehan discovered the specific pathways FGF uses to
activate stem cells or to keep them dormant. This discovery has major
implications for future cancer therapies."Current cancer therapies such as chemotherapy and radiation only target
actively proliferating cancer cells," Wang explained. "If we can
control how cancerous stem cells
remain dormant and how they are activated, we can cure cancer. The
research is still in the very early stages but we have hope."
This site is for information on the various Chemo treatments and Stem Cell Therapies since 1992. This journey became bitter sweet in 2014, with the passing of my beautiful and dear wife. Sherry, had fought Non - Hodgkins Lymphoma(NHL) since 1990, in and out of remissions time and time again. From T-Cell therapies(1990's) to Dual Cord Blood Transplant(2014), she was in Clinical Trials over the years. This site is for informational purpose only and is not to promote the use of certain therapies.
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