Researchers in Sydney have opened the door to a new treatment for
prostate cancer. They've identified three specific nutrients that
prostate cancer cells need to grow. Every year in Australia, more than 3,000 men die from prostate cancer and more than 20,000 men are told they have the disease. There may be a new treatment available, thanks to a breakthrough in
research conducted by a team led by Associate Professor Jeff Holst at
Sydney's Centenary Institute.
Jeff Holst states that what was discovered this time around is that prostate
cancer cells increase one of the pumps that bring a nutrient called
glutamine into the cells. If we can block the pumps that bring glutamine
into the cells, then we can actually starve the cancer cells and stop
them from growing.
If there's an increase in number of these pumps, that then gives us the
ability to try and target those pumps and block them selectively in the
cancer cells compared to the normal cells around them. At the
moment there's a lot of good therapies but no really good therapies for
late stage prostate cancer. And that's where these sort of compounds come in, if they can starve the cancer cells, they will stop them from
growing, a lot of men will die of old age rather than dying of prostate
cancer. The next step involves identifying a drug to switch off the nutrient pump. They, together with some researchers at the
University of Sydney, have the first such compounds that they are currently
testing, first of all in the cell models, but also they're moving into
what are called tumor explants where they take a piece of a patient's
prostate, grow it in a dish and put these compounds on and see if it's
able to stop the cells growing in that context.
I was diagnose with cancer when my dad died from cancer soon after I turned 5 years old. He was a physician and a wonderful man. He saved other people’s lives. He saved my best friend when she had spinal meningitis at the age of 4. We’ve been best friends ever since.
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