New approach for treating Skin Cancer

University of California, Irvine molecular biologists and their colleagues have identified an effective way to combat metastatic melanoma. Led by Alexander D. Boiko, UCI assistant professor of molecular biology & biochemistry at the Ayala School of Biological Sciences and the Sue and Bill Gross Stem Cell Center, the researchers discovered that blocking the cell surface protein, CD47 (known as a "don't eat me" signal), on melanoma cells, increased the degree by which these cells were phagocytosed, or "eaten," by macrophages. The team further discovered that blocking CD47 in combination with targeting a second cell surface protein, CD271, previously found to be expressed on melanoma initiating cells, resulted in virtually complete inhibition of metastases arising from human melanoma.