What causes Non-Hodgkin's Lymphoma?

The exact cause of non-Hodgkin lymphoma is unknown. However, there are multiple medical conditions that are associated with an increased risk of developing non-Hodgkin lymphoma:

• Inherited immune deficiencies: ataxia-telangectasia, Wiskott-Aldrich syndrome, common variable immunodeficiency, severe combined immunodeficiency, and X-linked lymphoproliferative syndrome
• Genetic syndromes: Down syndrome, Klinefelter's syndrome (a genetic condition in men caused by an extra X chromosome)
• Immune disorders, and their treatments: Sjögren's syndrome (an immune disorder characterized by unusual dryness of mucus membranes), rheumatoid arthritis, systemic lupus erythematosus
• Celiac disease, a disease involving the  processing of certain components of gluten, a protein in grains
• Inflammatory bowel disease, particularly Crohn’s disease, and its treatment
• Psoriasis
• Family history of lymphoma
• Bacteria: Helicobacter pylori, asssociated with gastritis and gastric ulcers; Borrelia burgdorferi, associated with Lyme disease; Campylobacter jejuni; Chalmydia psittaci
• Viruses: HIV, HTLV-1, SV-40, HHV-8, Epstein Barr virus, hepatitis virus
• Non-random chromosomal translocations and molecular rearrangements