The FDA has approved targeted therapies for the treatment of some
patients with the following types of cancer (some targeted therapies
have been approved to treat more than one type of cancer):
Adenocarcinoma of the stomach or gastroesophageal junction: Trastuzumab (Herceptin®)
Basal cell carcinoma: Vismodegib (Erivedge™)
Brain cancer: Bevacizumab (Avastin®), Everolimus (Afinitor®)
Breast cancer: Everolimus (Afinitor®), tamoxifen, toremifene (Fareston®), Trastuzumab (Herceptin®), fulvestrant (Faslodex®), anastrozole (Arimidex®), exemestane (Aromasin®), lapatinib (Tykerb®), letrozole (Femara®), pertuzumab (Perjeta™), ado-trastuzumab emtansine (Kadcyla™)
Colorectal cancer: Cetuximab (Erbitux®), Panitumumab (Vectibix®), Bevacizumab (Avastin®), Ziv-aflibercept (Zaltrap®), Regorafenib (Stivarga®)
Dermatofibrosarcoma protuberans: Imatinib mesylate (Gleevec®)
Head and neck cancer: Cetuximab (Erbitux®)
Gastrointestinal stromal tumor: Imatinib mesylate (Gleevec®), Sunitinib (Sutent®), Regorafenib (Stivarga®)
Giant cell tumor of the bone: Denosumab (Xgeva®)
Kaposi sarcoma: Alitretinoin (Panretin®)
Kidney cancer: Bevacizumab (Avastin®), Sorafenib (Nexavar®), Sunitinib (Sutent®), Pazopanib (Votrient®), Temsirolimus (Torisel®), Everolimus (Afinitor®), Axitinib (Inlyta®)
Leukemia: Tretinoin (Vesanoid®), Imatinib mesylate (Gleevec®), Dasatinib (Sprycel®), Nilotinib (Tasigna®), Bosutinib (Bosulif®), Rituximab (Rituxan®), Alemtuzumab (Campath®), Ofatumumab (Arzerra®), Obinutuzumab (Gazyva™)
Liver cancer: Sorafenib (Nexavar®)
Lung cancer: Bevacizumab (Avastin®), Crizotinib (Xalkori®), Erlotinib (Tarceva®), Gefitinib (Iressa®), Afatinib dimaleate (Gilotrif®), Ceritinib (LDK378/Zykadia)
Lymphoma: Tositumomab and 131I-tositumomab (Bexxar®), Ibritumomab tiuxetan (Zevalin®), Denileukin diftitox (Ontak®), Brentuximab vedotin (Adcetris®), Rituximab (Rituxan®), Vorinostat (Zolinza®), Romidepsin (Istodax®), Bexarotene (Targretin®), Bortezomib (Velcade®), Pralatrexate (Folotyn®), Lenaliomide (Revlimid®), Ibrutinib (Imbruvica™), Siltuximab (Sylvant™)
Melanoma: Ipilimumab (Yervoy®), Vemurafenib (Zelboraf®), Trametinib (Mekinist®), Dabrafenib (Tafinlar®)
Multiple myeloma: Bortezomib (Velcade®), Carfilzomib (Kyprolis®), Lenaliomide (Revlimid®), Pomalidomide (Pomalyst®)
Myelodysplastic/myeloproliferative disorders: Imatinib mesylate (Gleevec®)
Pancreatic cancer: Erlotinib (Tarceva®), Everolimus (Afinitor®), Sunitinib (Sutent®)
Prostate cancer: Cabazitaxel (Jevtana®), Enzalutamide (Xtandi®), Abiraterone acetate (Zytiga®), Radium 223 chloride (Xofigo®)
Soft tissue sarcoma: Pazopanib (Votrient®)
Stomach cancer: Ramucirumab (Cyramza™)
Systemic mastocytosis: Imatinib mesylate (Gleevec®)
Thyroid cancer: Cabozantinib (Cometriq™), Vandetanib (Caprelsa®), Sorafenib (Nexavar®)
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